SCIE. 2019; 30(2): 107-111 | DOI: 10.14744/scie.2019.72692

Cord Blood Vitamin D Level in Neonates of Preeclamptic Mothers

Didem Arman¹, Secil Ercin², Sevilay Topcuoðlu¹, Ayþem Kaya³, Fahri Ovalý⁴, Guner Karatekin^1
1Department of Pediatrics, Division of Neonatology, University of Health Sciences Zeynep Kamil Maternity and Children’s Training and Research Hospital, Ýstanbul, Turkey
²Department of Pediatrics, Division of Neonatology, American Hospital, Ýstanbul, Turkey
³Department of Biochemistry, Institute of Cardiology, Ýstanbul University, Ýstanbul, Turkey
⁴Department of Pediatrics, Neonatal Intensive Care Unit, Ýstanbul Medeniyet University Göztepe Training and Research Hospital Ýstanbul, Turkey

INTRODUCTION: Vitamin D deficiency may play a role in the pathogenesis of preeclampsia by causing abnormal placental implantation and by affecting the inflammatory response. The aim of this study was to compare the cord blood vitamin D level in neonates born to preeclamptic mothers with that of a control group of newborns whose mothers were not preeclamptic.
METHODS: The preeclamptic group was made up of newborns of mothers classified as having moderate to severe preeclampsia. Neonates of a similar gestational age and birth weight born to normotensive mothers comprised the control group. The cord blood vitamin D level of both groups of newborns was measured and the results were statistically compared.
RESULTS: Sixty neonates born to preeclamptic mothers and 47 born to normotensive mothers were included in the study. The mean serum vitamin D level of the study group was 12.62±5.43 ng/mL and 12.85±5.56 ng/mL in the control group. The percentage of those determined to have a serum vitamin D level <20 ng/mL in the study and the control groups was 89.5% and 88.9%, respectively. The serum magnesium level in the study group was statistically greater than that observed in the control group (p<0.001).
DISCUSSION AND CONCLUSION: The cord blood vitamin D level of those born to preeclamptic mothers was not found to be statistically different when compared with the vitamin D level of neonates of normotensive mothers.

Keywords: Cord blood, preeclampsia; vitamin D.

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Preeklamptik Anne Bebeklerinde Kordon Kaný D Vitamini Düzeylerinin Deðerlendirilmesi

Didem Arman¹, Secil Ercin², Sevilay Topcuoðlu¹, Ayþem Kaya³, Fahri Ovalý⁴, Guner Karatekin^1
1Saðlýk Bilimleri Üniversitesi, Zeynep Kamil Eðitim ve Araþtýrma Hastanesi, Pediatri, Yenidoðan Yoðun Bakým Kliniði, Ýstanbul
²Amerikan Hastanesi, Pediatri Kliniði, Ýstanbul
³Istanbul Üniversitesi, Kardiyoloji Enstitüsü, Biyokimya Kliniði, Ýstanbul
⁴Istanbul Medeniyet Üniversitesi, Pediatri, Yenidoðan Yoðun Bakým Kliniði, Ýstanbul

GÝRÝÞ ve AMAÇ: D vitamini eksikliðinin, preeklampsi patogenezinde enflamatuvar cevap ve immün fonksiyonlar üzerine etki ederek riski arttýrdýðý düþünülmektedir. Çalýþmamýzda preeklamptik anne bebeklerinde kord kaný D vitamini düzeylerini kontrol grubuyla karþýlaþtýrmayý amaçladýk.
YÖNTEM ve GEREÇLER: Çalýþma ileriye yönelik olarak düzenlendi. Çalýþma grubuna orta ve aðýr preeklampsi tanýsý almýþ olan preeklamptik annelerin bebekleri alýndý. Annesi preeklamptik olmayan, gestasyonel yaþ ve aðýrlýklarý çalýþma grubu ile benzer özellikte yenidoðanlar kontrol grubu olarak seçildi. Kordon kaný D vitamini düzeyleri bakýlarak istatistiksel olarak karþýlaþtýrýldý.
BULGULAR: Çalýþmaya 60 preeklamptik anne bebeði ve kontrol grubu olarak 47 normotansif anne bebeði dahil edildi. Preeklamptik anne bebekleri ve kontrol grubundaki bebeklerin ortalama 25 hidroksi D vitamini (25OH D) vitamini düzeyleri sýrasýyla 12.62±5.43 ve 12.85±5.56 ng/mL olarak bulundu. Çalýþma grubunun %89.5’inde 25(OH) D vitamini düzeyi <20 ng/mL iken kontrol grubunda bu oran %88.9 idi. Her iki grup arasýnda vitamin D, kalsiyum ve fosfor düzeyleri açýsýndan istatistiksel olarak anlamlý farklýlýk saptanmadý (p>0.05). Çalýþma grubundaki bebeklerin magnezyum deðerleri, kontrol grubundakilere göre anlamlý düzeyde yüksekti (p<0.01).
TARTIÞMA ve SONUÇ: Çalýþmamýzda preeklamptik anne bebeklerinin kordon kaný D vitamini düzeylerinin normotansif anne bebeklerinin düzeylerine göre herhangi bir farklýlýk göstermediði saptanmýþtýr.

Anahtar Kelimeler: D vitamini, kordon kaný; preeklampsi.

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